I recently updated my Internet Explorer to Internet Explorer 8. Once I completed the upgrade it complained the some of my programs installed didn't work well with IE8. One of these, was Skype.
The solution to this problem was to update to the latest version of Skype. However when I completed the update of Skype I always got the same error while openning IE:
An unhandled win32 exception occurred in iexplorer [4992]
If you are getting the same error try uninstalling the web features of Skype.
Go to Control Panel
Then go to Programs and features
Find Skype we features and uninstall it.
This should make your problem go away.
